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美嘉儀器公司在原廠的獨家授權下,
結合 Andor, Roper Scientific,
Hamamatsu CCD Camera 及 Leica 的顯微鏡技術,
同時, 包括顯微影像系統自動化的硬體設備,
在國內, 提供完善的技術支援與服務. |
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MetaMorph
高階影像處理分析軟體,
擁有全世界最大的使用客戶群.
目前最新版本為 Version 7.6 本公司培訓多名技術專員,
多年以來, 已提供國內許多客戶相關應用.
目前, 已派員前往學習最新版本的技術與應用.
MetaMorph
享有的榮譽 :
1).
全世界學術界使用率最高及評價第一的軟體
2).
全台灣學術界使用率最高及評價第一的軟體
在台灣,
我們已提供服務超過上百套 MetaMorph
軟體, 包括其顯微影像自動擷取分析系統.
客戶包括全國各大學及研究單位.
在中國大陸, 目前與上海威涵光電公 策略合作,
其所安裝的系統也是佔中國的主導地位.
詳細資料,
請點選左圖
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Brochures
Datasheets and Spec Sheets
Posters & Presentations
|
|
| MataMorph
V. 7.6 提供最新三種應用模組 Angiogenesis
Application Module , Count Nuclei/
Cell Scoring Application Module for
MetaMorph, Neurite Outgrowth (
同時, 也包括更多的硬體支援功能,
例如 Yokogawa
CSU 共軛焦掃描器,
CARV-II 掃描器 ........... 等 ) |
|
Angiogenesis
Application Module for MetaMorph |
 |
| Left:
original image, right: segmented
images shows tubes (white) and nodes
(green). |
|
Count
Nuclei/ Cell Scoring Application
Module for MetaMorph |
 |
| Left:
original image, right: segmented
images shows nuclei. |
 |
| Left:
original image, right: segmented
images shows two different probes. |
 |
|
MetaMorph
Premier has all the
device drivers and most of the
advanced processing capabilities
built in (multi-dimensional
imaging, fluorescence
overlay, image
stitching, motion
analysis, and colocalization)
for the researcher who wants maximum
flexibility. The only option to
select is the specific camera driver
required.
MetaMorph
Basic
has a robust
set of image acquisition,
processing, and analysis tools built
in, and is a more affordable
solution for the budget conscious
researcher. Specific device drivers
and the advanced analysis
capabilities are optional and can be
added as needed. This way, you only
purchase the device drivers, camera
driver, and advanced analysis
capabilities you need now. You can
always add on additional
capabilities or device drivers later
as your needs change.
Standard
features in MetaMorph Premier and
MetaMorph Basic include time lapse,
spectral scan, and Z-series (with
Z-motor driver) acquisition, image
and stack processing such as Fast
Fourier Transform (FFT), arithmetic
operations, morphology filters,
shading correction and background
subtraction, 2D deconvolution,
morphometry and distance
measurements, and more.
MetaMorph
Offline has the
analysis capabilities of either
MetaMorph Premier or MetaMorph Basic
without external devices control. It
is a very cost effective solution
for the researcher who has an
alternate image source or other
MetaMorph systems. MetaMorph
Offline's purpose is to load,
process, and save images. It is very
popular in multi-user facilities
because it frees up the more
expensive hardware acquisition
systems by providing users offline
analysis after acquisition.
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| MetaMorph
provides many powerful
automation tools to simplify
experiments and increase speed
and reliability, such as device
controls, system automation, and
journals.
Journals are
similar to a macro and they
record the actions of a
MetaMorph user. They can be
executed by other journals and
can be edited.
The software
includes standard interfaces for
illumination, stage, and Z-motor
devices, and it provides digital
I/O to communicate with unique
devices.
|
Journaling
and device controls can:
- Control the
illumination wavelength,
employing filter wheels,
shutters, liquid crystal
tunable filters,
monochromators, or other
wavelength selectors
- Synchronize
image acquisition and
analysis with the opening
and closing of shutters
- Scan slides
or multi-well plates with a
motorized stage
- Acquire
images of a through-focus
Z-series for subsequent
deconvolution and 3D
reconstruction
- Control
custom devices that accept
commands through a serial or
parallel port connection
- Auto-focus
at multiple stage positions
or at specific intervals in
a time lapse environment
|
Automated
microscope controls can help you
automate your system by:
- Rotating
objectives, change filter
cube settings, open and
close the shutter, switch
the illumination lamp on or
off, and change the lower
and upper prism positions
- Controlling
the X, Y, and Z-axis
positioning of a stage, move
the stage, and store the
positions for future use
- Controlling
automated stages to capture
multiple locations in a
sample or multiple samples,
including dishes and
multi-well plates
- Using focus
motors to collect Z-series
or through-focal image sets
- Acquiring
images using eight different
groups of settings for
wavelength, intensity, and
exposure duration
- Acquiring a
spectral scan in a range of
excitation or emission
wavelengths
- Capturing a
time lapse series of images
at specified intervals and
durations
|
Standard
Features
( with
MetaMorph Premier and Basic
systems)
- Binary and
8-, 16-, 24-, 48-bit image
display and processing
- Stack
display and processing
including best focus,
montage, topographical
surface, view orthogonal
planes, and create movie
- Over 20
morphology filters,
including erode, dilate,
skeletonize, outline, and
segment
- Arithmetic
operations including add,
subtract, multiply, divide,
logical AND, OR, XOR,
minimum, maximum, and
average
- Fast
Fourier Transform (FFT)
- Shading
correction and background
subtraction
- Filters
including sharpen, low pass,
detect edges, unsharp mask,
median filter, remove haze,
and custom kernels
- 2D
deconvolution ( nearest
neighbors and no
neighbors)
- 3D
reconstruction
- FRET
- Auto expose
from digital cameras
- Time lapse
acquisition
- Spectral
scan acquisition
- Z-series
acquisition ( with Z-motor
driver )
- Morphometry
and distance measurements
including area, hole area,
standard area count,
perimeter, centroid X and Y,
Z-position, width, length
and height, orientation,
breadth, fiber length, fiber
breadth, shape factor,
elongated form factor, inner
radius, outer radius, mean
radius, equivalent radius,
equivalent spheroid volume,
equivalent prolate volume,
equivalent oblate volume,
equivalent sphere surface
area, average, gray value,
total gray value, optical
integrated density (OD),
integrated OD, intensity
center X and Y, radial
dispersion, texture
difference moment, texture
inverse difference moment,
OD variance, OD relative
low/medium or high areas, OD
relative low/medium or high
amounts, OD relative
low/medium or high
distances, and others
including over 30 elliptical
Fourier parameters to assist
in defining shape analysis
patterns
- Color-combine
and separate 24-bit or
48-bit images
- Regions of
interest tools
- Image
histogram
- Data
logging and exporting to
text file or spreadsheet
programs that support DDE
(Dynamic Data Exchange) such
as Microsoft® Excel
- Automation
through journals and
taskbars
- Customizable
toolbars and windows
- Presentation
features including organize
and label with text, date,
time, or calibration bars,
convert color images to
monochrome, produce
intensity profile images,
create image montages and
movies, overlay images, and
document the operations
performed on the images
|
Microscope
Control Options (
顯微鏡自動化控制功能
)
- Most popular automated
microscope models from Leica,
Nikon, Olympus, and Zeiss
- Digital auto-focus
- XY stage device control
for popular models from
major manufacturers
- Z-axis device control for
popular models from major
manufacturers
- Piezo-actuated Z and XY
device control
- Monochromator control for
illumination
- Filter wheel and shutter
control
- UniBlitz® shutters
- AOTF for laser control
- Liquid Crystal tunable
filters
- Custom I/O (RS-232 serial
and TTL parallel)
Acquisition
Options ( 影像擷取控制選配
)
- Digital CCD
cameras, both monochrome and
color, including: cooled,
full frame, frame transfer,
interline, back thinned,
intensified, and on-chip
multiplication gain, from
major manufacturers
- Video
cameras, both monochrome and
color, including: RS-170,
CCIR, on-chip integration,
intensified, CCD, and tube,
from major manufacturers
- Simultaneous
acquisition from two cameras
or control of an image
splitting device for
projection of two or four
emission wavelengths onto a
single camera (appropriate
hardware required)
- Wavelength
streaming and/or Z-axis
streaming ( 專利設計
)
Optional
Features for Basic Systems
(
MetaMorph Premier systems
包括此部分軟體功能
)
-
Multi-dimensional
imaging
-
Overlay
multi-fluorescent images
-
Image
stitching
-
Motion
analysis and particle
tracking
-
Colocalization
and correlation measurements
Additional
Modules (
選配軟體模組
)
-
3D
deconvolution
-
Advanced 3D
visualization
-
Neurite
outgrowth
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一些主要應用包括
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| P/N. |
MetaMorph
Software Packages (
選購參考 -
請洽本公司專員 )
|
| 4000 |
MetaMorph
Basic system - does not include
acquisition options, device drivers,
or optional dropins |
| 4001 |
MetaMorph
Basic system/current user - does not
include acquisition option(s), device
drivers, or optional dropins |
| 4002 |
MetaMorph
Premier
- includes all
device drivers and optional dropins -
does not include acquisition option(s) |
| 4003 |
MetaMorph
Premier
/
current user - includes all
device drivers and optional dropins -
does not include acquisition option(s) |
|
Acquisition
Options for MetaMorph Basic and
MetaMorph Complete |
|
Princeton
Instruments acquisition option for
digital cameras |
|
Photometrics
acquisition option for digital
cameras. Includes CoolSNAP FX and HQ
(Not for CoolSNAP color camera, see
part number 31214) |
|
Twin
Camera simultaneous acquisition option
for Photometrics. Requires 40052
SplitView dropin and 40076
Photometrics acquisition option |
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MuTech
MV1500 acquisition option. Drivers,
board, and cable for Hamamatsu
ORCA-100/II/ER, C4880-10/-80 cameras |
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IEEE1394
Acquisition Option for Orca-100 or ER |
|
CoolSNAP
Color acquisition option.
Drivers and dropin for
acquisition with CoolSNAP COLOR
CCD camera (not CoolSNAP FX/HQ camera.
See 40052 for FX/HQ driver) |
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Spot
acquisition option.
Drivers and dropin for
acquisition with Spot-I/II/RT color
CCD camera. |
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Nikon
DXM-1200 camera acquisition option.
Drivers and dropin for
acquisition with the Nikon DXM-1200
digital color camera |
|
FlashBus
acquisition option with generic RGB,
Y/C, & Composite cable. Includes 9
pin to 4BNC RGBS adapter cable.
Drivers, FlashBus PCI frame
grabber, and cables. |
|
FlashBus
acquisition option with DAGE 300
cable.
Drivers, FlashBus PCI frame
grabber, and cables for image
acquisition from DAGE 300 monochrome
video camera or any RS-170 B&W
video camera |
|
FlashBus
acquisition option with DAGE 330
cable.
Drivers, FlashBus PCI frame
grabber, and cables for image
acquisition from DAGE 330 color video
camera or any 9 pin RGB video
connector. |
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Twain
only acquisition from Twain compliant
devices.
(Included with any of the above
acquisition options) |
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Hamamatsu
Phoenix Frame Grabber Kit |
|
Laser
control driver for Photobleaching |
|
Device
Drivers for MetaMorph Basic
(included with MetaMorph Complete) |
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Illumination
Option:
Drivers to add control of
illumination devices including filter
wheels, shutters, monochromators, and
liquid crystal tunable filters. |
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CARV-II
confocal module device option. |
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CRI
MicroColor RGB filter option.
(Included with Illumination
option) |
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UniBlitz
shutter driver only (this is included
with 40010 Illumination option) |
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Input/Output
option: Driver and dropin for control
of custom RS232 (serial) and digital
(parallel) devices |
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Digital
Autofocus:
requires Z-axis device driver |
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Ludl/ASI
XYZ (stage and Z-Motor) device
option for control of Ludl or ASI
motorized XY stage and Z axis |
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Ludl/ASI
Z-axis only driver for Ludl or
ASI Z-motor only (this is included
with 40011 Ludl/ASI
device option) |
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Prior
XYZ (stage and Z-Motor) device option
driver for control of Prior Z-motors
and stages |
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Prior
Z-axis only driver for control of
Prior Z-motor (this is included with
40039 Prior device option) |
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PiFOC
piezo electric fast focus driver
Requires (40090 or 40098 DAQ boards) |
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Analog
input option -Synchronous.
(Requires 40090 DAQboard2000) |
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DAQboard2000
PCI board, cable, and driver kit
(Requires 40093, 30847, or 40010) |
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DDA02
PCI DAQ board, cable, and driver
(Requires 30847 or 40010) |
|
Nikon
Z-motor option driver for Nikon Z
focus motor |
|
Marzhauser
XYZ (stage and Z-Motor) device option
driver for control of Marzhauser stage
and focus motor |
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Marzhauser
Z-axis only driver for control of
Marzhauser Z-motor (this is included
with 40073 device option) |
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Nikon
E1000 automated microscope control
driver and dropin |
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Zeiss
scope control: Drivers and dropin for
controlling Zeiss automated
microscopes (ONLY works with Zeiss
scopes supported by the Zeiss
Micro-Toolbox/32 software). |
|
Leica
scope control:
Drivers and dropin for
controlling Leica automated
microscopes |
|
Olympus
scope control: Drivers and dropin for
controlling AX series automated
microscopes |
|
Linkam
device option:
Control for Linkam XY stage
with Heating/Cooling control. |
|
Optional
Dropins for MetaMorph Basic (included
with MetaMorph Complete) |
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3D
measurement option - Measure XYZ
Distance and
Measure Volume drop-ins |
|
Co-localization
and Overlay fluorescence option |
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Motion
Option: Dropins for automatic tracking
(track objects) and semi-automated
tracking of objects (track points) |
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Multidimensional
Acquisition only dropin.
Dropin for Multiparameter
(time, wavelength, z-series, stage
position) acquisition |
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Multidimensional
Viewer only dropin.
Dropin for Multiparameter
(time, wavelength, z-series, stage
position) viewing |
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Multidimensional
Acquisition/Viewer dropin.
Dropin for Multiparameter
(time, wavelength, z-series, stage
position) acquisition and viewing |
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Z/Wavelength
Stream option.
Requires Z and/or illumination
device drivers |
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Digital4
dropin option for Spot or Generic
digital cameras (Spot cam. also
requires 30990 Spot acquisition ) |
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Measure
Grid Dropin |
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SplitView
dropin for a single image to dual
emission optical image splitter.
Requires the Optical Insights
Multispec Micro-Imager or the
Hamamatsu W-View emission splitter, or
a dual camera image/wavelength
splitter with the Twin Camera (40054)
dropin. |
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Angiogenesis
Application Module |
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Count
Nuclei/ Cell Scoring Application
Module |
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Neurite
Outgrowth Application Module |
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Additional
Modules for MetaMorph (NOT
included with MetaMorph Complete) |
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AutoQuant
Widefield 3D deconvolution for
MetaMorph |
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AutoQuant
Confocal 3D deconvolution for
MetaMorph |
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PSF-based
Constrained Iterative 3D Deconvolution |
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Bundled
Sets of Offline Analysis Software |
|
MetaMorph
(Basic or Full) offline, MetaFluor
offline, and MetaMorph/MetaFluor
offline combos are offered in bundled
sets of three, five and ten
at reduced pricing.
These sets will be delivered
with one
CD, one install code, and X number of
keys each having the same key ID
number.
The bundled set of keys will
all be treated the same when software
updates become available.
They can never be broken apart
and you can not add a drop-in to one
without buying the same drop-in for
the others in a given bundled set.
A single key in a set can not
be converted into an acquisition
system without buying the acquisition
upgrade for all the keys in that
bundled set.
Software updates for a bundled
set must be purchased for all the keys
in that set (can not be purchased
individually).
We have a software update
pricing policy to help with this (see
below). Please
make sure that your customer
understands what a bundled set is and
its’ policies |
|
MetaMorph
Basic Offline/current User (Can't acquire images without 31033 Acquisition upgrade and
an Acquisition Option) |
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Set
of 3 MetaMorph offline packages |
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Set
of 5 MetaMorph offline packages |
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Set
of 10 MetaMorph offline packages |
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Set
of 3 MM colocalization/overlay
options: Must be purchased with Set of
3 MM offlines |
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Set
of 5 MM colocalization/overlay
options: Must be purchased with Set of
5 MM offlines |
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Set
of 10 MM colocalization/overlay
options: Must be purchased with Set of
10 MM offlines |
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Set
of 3 MM MultiDimensional viewer only
options: Must be purchased with Set of
3 MM offlines |
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Set
of 5 MM MultiDimensional viewer only
options: Must be purchased with Set of
5 MM offlines |
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Set
of 10 MM MultiDimensional viewer only
options: Must be purchased with Set of
10 MM offlines |
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Set
of 3 MM Motion options - Track
Points/Track Objects.
Must be purchased with Set of 3
MM offlines |
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Set
of 5 MM Motion options - Track
Points/Track Objects.
Must be purchased with Set of 5
MM offlines |
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Set
of 10 MM Motion options - Track
Points/Track Objects.
Must be purchased with Set of
10 MM offlines |
| |
TIP:
If a customer is considering a
purchase of the above Bundled sets of
MM-Basic offline packages AND two or
more bundled sets of dropin options,
you should offer them the
bundle set of MM-Complete
Offline
listed below.
It will give them all the
optional dropins for the same price or
less. |
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MetaMorph
Complete Offline current user
(Includes all Optional Dropins except
"Screening" and no device
drivers) |
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Set
of 3 MetaMorph Complete Offline
packages (Includes all Optional
Dropins except "Screening"
and no device drivers) |
|
Set
of 5 MetaMorph Complete Offline
packages (Includes all Optional
Dropins except "Screening"
and no device drivers) |
|
Set
of 10 MetaMorph Complete Offline
packages (Includes all Optional
Dropins except "Screening"
and no device drivers) |
| |
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Updates,
Upgrades & Reconfigurations |
|
One
key software update to current version
for any configuration of Meta Series
imaging software (key ID number
required) |
|
Two
keys software update to current
version for any configuration of Meta
Series imaging software (key ID
numbers req.) |
|
Three
or more keys software update to
current version for any config. of
Meta Series software (key ID numbers
required) |
|
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MetaMorph
Basic Offline to Acquisition Upgrade:
Upgrades one MM Basic offline
system to an acquisition system.
Also requires a MM Acquisition
option. |
|
MetaMorph
Complete Offline to Acquisition
Upgrade:
Upgrades one MM Complete
Offline system to an acquisition
system.
Also requires a MM Acquisition
option. Includes all optional Device
Drivers. |
|
MetaMorph
System Reconfiguration Fee:
For a customer that has any two
MetaMorphs with different
configurations and wants to transfer a
hardware Device Driver, Dropin, or
Acquisition Option
from one system to the other.
Software must be current
version.
If not current version,
software updates must be purchased
also. |
|
SPECIAL:
FlashBus upgrade for old Meteor video
board users.
Replaces older Meteor video
capture board with current FlashBus
board , driver, and upgrade to current
MM software release |
|
學術界發表論文
- 部分摘要 ( 每年皆有 1000
篇以上, 採用 MetaMorph 軟體所完成的重要論文發表
) |
|
Li CY, Wang Y,
Cui ZS, Wang EH (2005)
Expression of T cell factor-4 in
non-small-cell lung cancer. Chinese
Medical Journal. 118
:136-40.
Kojima H., Uemura T. (2005)
Strong and Rapid Induction of
Osteoblast Differentiation by
Cbfa1/Til-1 Overexpression for
Bone Regeneration Journal
of Biological Chemistry. 280
:2944-2953.
Barbato J. E, Zuckerbraun B.
S, Overhaus M., Raman K. G,
Tzeng E. (2005) Nitric Oxide
Modulates Vascular Inflammation
and Intimal Hyperplasia in
Insulin-Resistance and the
Metabolic Syndrome American
Journal of Physiology: Heart and
Circulatory Physiology.
:00982.2004.
Yarar D., Waterman-Storer C.
M., Schmid S. L. (2005) A
Dynamic Actin Cytoskeleton
Functions at Multiple Stages of
Clathrin-mediated Endocytosis Molecular
Biology of the Cell. 16
:964-975.
Paganoni S., Ferreira A.
(2005) Neurite extension in
central neurons: a novel role
for the receptor tyrosine
kinases Ror1 and Ror2 Journal
of Cell Science. 118
:433-446.
Seong E., Wainer B. H.,
Hughes E. D., Saunders T. L.,
Burmeister M., Faundez V. (2005)
Genetic Analysis of the Neuronal
and Ubiquitous AP-3 Adaptor
Complexes Reveals Divergent
Functions in Brain Molecular
Biology of the Cell. 16
:128-140.
Gupton S. L., Anderson K. L.,
Kole T. P., Fischer R. S., Ponti
A., Hitchcock-DeGregori S. E.,
Danuser G., Fowler V. M., Wirtz
D., Hanein D., Waterman-Storer
C. M. (2005) Cell migration
without a lamellipodium:
translation of actin dynamics
into cell movement mediated by
tropomyosin Journal
of Cell Biology. 168
:619-631.
Liao D., Lin H., Law P. Y.,
Loh H. H. (2005) Mu-opioid
receptors modulate the stability
of dendritic spines Proceedings
of the National Academy of
Sciences. 102 :1725-1730.
DeLuca J. G., Dong Y.,
Hergert P., Strauss J., Hickey
J. M., Salmon E. D., McEwen B.
F. (2005) Hec1 and Nuf2 Are Core
Components of the Kinetochore
Outer Plate Essential for
Organizing Microtubule
Attachment Sites Molecular
Biology of the Cell. 16
:519-531.
Hilliard M. A, Apicella A. J,
Kerr R., Suzuki H., Bazzicalupo
P., Schafer W. R (2005) In vivo
imaging of C. elegans ASH
neurons: cellular response and
adaptation to chemical
repellents EMBO
Journal. 24 :63-72.
Karagiannis J., Bimbo A.,
Rajagopalan S., Liu J.,
Balasubramanian M. K. (2005) The
Nuclear Kinase Lsk1p Positively
Regulates the Septation
Initiation Network and Promotes
the Successful Completion of
Cytokinesis in Response to
Perturbation of the Actomyosin
Ring in Schizosaccharomyces
pombe Molecular
Biology of the Cell. 16
:358-371.
Lee W.-K., Bork U.,
Gholamrezaei F., Thevenod F.
(2005) Cd2+-induced cytochrome c
release in apoptotic proximal
tubule cells: role of
mitochondrial permeability
transition pore and Ca2+
uniporter American
Journal of Physiology: Renal
Physiology. 288 :F27-39.
Choudhuri T., Pal S., Das T.,
Sa G. (2005) Curcumin
selectively induces apoptosis in
deregulated cyclin D1 expressed
cells at G2 phase of cell cycle
in a p53-dependent manner Journal
of Biological Chemistry.
:M410670200.
Fujita H., Fukuhara S.,
Sakurai A., Yamagishi A.,
Kamioka Y., Nakaoka Y., Masuda
M., Mochizuki N. (2005) Local
Activation of Rap1 Contributes
to Directional Vascular
Endothelial Cell Migration
Accompanied by Extension of
Microtubules on Which RAPL, a
Rap1-associating Molecule,
Localizes Journal
of Biological Chemistry. 280
:5022-5031.
Vyas A. A., Blixt O., Paulson
J. C., Schnaar R. L. (2005)
Potent glycan inhibitors of
myelin-associated glycoprotein
enhance axon outgrowth in vitro Journal
of Biological Chemistry.
:M500250200.
Maxwell C. A., Keats J. J.,
Belch A. R., Pilarski L. M.,
Reiman T. (2005) Receptor for
Hyaluronan-Mediated Motility
Correlates with Centrosome
Abnormalities in Multiple
Myeloma and Maintains Mitotic
Integrity Cancer
Research. 65 :850-860.
Jeong H.-W., Nam J.-O., Kim
I.-S. (2005) The COOH-terminal
End of R-Ras Alters the Motility
and Morphology of Breast
Epithelial Cells through Rho/Rho-Kinase
Cancer
Research. 65 :507-515.
Barbas H., Medalla M., Alade
O., Suski J., Zikopoulos B.,
Lera P. (2005) Relationship of
Prefrontal Connections to
Inhibitory Systems in Superior
Temporal Areas in the Rhesus
Monkey Cerebral
Cortex. :bhi018.
Kole T. P., Tseng Y., Jiang
I., Katz J. L., Wirtz D. (2005)
Intracellular Mechanics of
Migrating Fibroblasts Molecular
Biology of the Cell. 16
:328-338.
Pratt S. J., Epple H., Ward
M., Feng Y., Braga V. M.,
Longmore G. D. (2005) The LIM
protein Ajuba influences p130Cas
localization and Rac1 activity
during cell migration Journal
of Cell Biology. 168
:813-824.
|
|
Alan R Schenkel,
Zahra Mamdouh, William A Muller
(2004) Locomotion of monocytes
on endothelium is a critical
step during extravasation. Nature
Immunology. :.
Shin-ichiro Kojima, Danijla
Vignjevic, Gary G. Borisy (2004)
Improved silencing vector
co-expressing GFP and small
hairpin RNA BioTechniques.
36(1) :74-79.
J.
Moffat, B. Andrews (2004)
Late-G1 cyclin-CDK activity is
essential for control of cell
morphogenesis in budding yeast Nature
Cell Biology. 6(1) :59-66.
M.
Miaczynska, S.
Christoforidis, A. Giner, A.
Shevchenko, S. Uttenweiler-Joseph,
B. Haberman, M. Wilm, R.G.
Parton, M. Zerial (2004) APPL
Proteins Link Rab5 to Nuclear
Signal Transduction via an
Endosomal Compartment Cell.
116 :445-456.
Young L. W., Wilen R. W.,
Bonham-Smith P. C. (2004) High
temperature stress of Brassica
napus during flowering reduces
micro- and megagametophyte
fertility, induces fruit
abortion, and disrupts seed
production Journal
of Experimental Botany. 55
:485-495.
Alvarado M. C., Zsigmond L.
M., Kovacs I., Cseplo A., Koncz
C., Szabados L. M. (2004) Gene
Trapping with Firefly Luciferase
in Arabidopsis. Tagging of
Stress-Responsive Genes Plant
Physiology. 134 :18-27.
Bove C. M., Yang Z., Gilson
W. D., Epstein F. H., French B.
A., Berr S. S., Bishop S. P.,
Matsubara H., Carey R. M.,
Kramer C. M. (2004) Nitric Oxide
Mediates Benefits of Angiotensin
II Type 2 Receptor
Overexpression During
Post-Infarct Remodeling Hypertension.
:.
Ertugrul M. Ozbudak, Mukund
Thattai, Han N. Lim, Boris I.
Shraiman, Alexander van
Oudenaarden (2004)
Multistability in the lactose
utilization network of
Escherichia coli. Nature.
427 :737 - 740.
Derdowski A., Ding L.,
Spearman P. (2004) A Novel
Fluorescence Resonance Energy
Transfer Assay Demonstrates that
the Human Immunodeficiency Virus
Type 1 Pr55Gag I Domain Mediates
Gag-Gag Interactions Journal
of Virology. 78 :1230-1242.
Tracy T. Cao, Wakam Chang,
Sarah E. Masters, and Mark S.
Mooseker (2004) Myosin-Va Binds
to and Mechanochemically Couples
Microtubules to Actin Filaments Molecular
Biology of the Cell. 15
:151-161.
Morabito M. A., Sheng M.,
Tsai L.-H. (2004) Cyclin-Dependent
Kinase 5 Phosphorylates the
N-Terminal Domain of the
Postsynaptic Density Protein
PSD-95 in Neurons Journal
of Neuroscience. 24
:865-876.
Iwata N., Mizukami H.,
Shirotani K., Takaki Y.,
Muramatsu S.-i., Lu B., Gerard
N. P., Gerard C., Ozawa K.,
Saido T. C. (2004) Presynaptic
Localization of Neprilysin
Contributes to Efficient
Clearance of Amyloid-{beta}
Peptide in Mouse Brain Journal
of Neuroscience. 24
:991-998.
Levi S., Logan S. M., Tovar
K. R., Craig A. M. (2004)
Gephyrin Is Critical for Glycine
Receptor Clustering But Not for
the Formation of Functional
GABAergic Synapses in
Hippocampal Neurons Journal
of Neuroscience. 24
:207-217.
Tang X.-Q., Tanelian D. L.,
Smith G. M. (2004) Semaphorin3A
Inhibits Nerve Growth
Factor-Induced Sprouting of
Nociceptive Afferents in Adult
Rat Spinal Cord Journal
of Neuroscience. 24
:819-827.
Obrietan K., Hoyt K. R.
(2004) CRE-Mediated
Transcription Is Increased in
Huntington's Disease Transgenic
Mice Journal
of Neuroscience. 24
:791-796.
Stutzmann G. E., Caccamo A.,
LaFerla F. M., Parker I. (2004)
Dysregulated IP3 Signaling in
Cortical Neurons of Knock-In
Mice Expressing an
Alzheimer's-Linked Mutation in
Presenilin1 Results in
Exaggerated Ca2+ Signals and
Altered Membrane Excitability Journal
of Neuroscience. 24
:508-513.
Liu Y., Berndt J., Su F.,
Tawarayama H., Shoji W., Kuwada
J. Y., Halloran M. C. (2004)
Semaphorin3D Guides Retinal
Axons along the Dorsoventral
Axis of the Tectum Journal
of Neuroscience. 24
:310-318.
Lindgens D., Holstein T. W.,
Technau U. (2004) Hyzic, the
Hydra homolog of the zic/odd-paired
gene, is involved in the early
specification of the sensory
nematocytes Development.
131 :191-201.
le Noble F., Moyon D.,
Pardanaud L., Yuan L., Djonov
V., Matthijsen R., Breant C.,
Fleury V., Eichmann A. (2004)
Flow regulates arterial-venous
differentiation in the chick
embryo yolk sac Development.
131 :361-375.
D. M. Brown, K. Donaldson, P.
J. Borm, R. P. Schins, M.
Dehnhardt, P. Gilmour, L. A.
Jimenez, and V. Stone (2004)
Calcium and ROS-mediated
activation of transcription
factors and TNF- cytokine gene
expression in macrophages
exposed to ultrafine particles American
Journal of Physiology: Lung
Cellular and Molecular
Physiology. 286 :344-353.
|
|
Wong A. Y. C.,
Graham B. P., Billups B.,
Forsythe I. D. (2003)
Distinguishing between
Presynaptic and Postsynaptic
Mechanisms of Short-Term
Depression during Action
Potential Trains. Journal
of Neuroscience. 23
:4868-4877.
Lee J.-Y., Goldstein B.
(2003) Mechanisms of cell
positioning during C. elegans
gastrulation Development.
130 :307-320.
Nakamichi Y., Ohara-Imaizumi
M., Ishida H., Nagamatsu S.
(2003) An insulin-related
peptide expressed in 3T3L1
adipocytes is localized in GLUT4
vesicles and secreted in
response to exogenous insulin,
which augments the
insulin-stimulated glucose
uptake Journal
of Cell Science. 116 :73-79.
Baena-Lopez L. A., Garcia-Bellido
A. (2003) Genetic requirements
of vestigial in the regulation
of Drosophila wing development Development.
130 :197-208.
Leonard A. S., Yermolaieva
O., Hruska-Hageman A., Askwith
C. C., Price M. P., Wemmie J.
A., Welsh M. J. (2003) cAMP-dependent
protein kinase phosphorylation
of the acid-sensing ion
channel-1 regulates its binding
to the protein interacting with
C-kinase-1. Proceedings
of the National Academy of
Sciences. 100 :2029-2034.
Joshua C. Nickols, William
Valentine, Sujata Kanwal, Bruce
D. Carter (2003) Activation of
the transcription factor NF-B in
Schwann cells is required for
peripheral myelin formation. Nature
Neuroscience. 6 :161-167.
Geri
Kreitzer, Jan
Schmoranzer, Seng Hui Low, Xin
Li, Yunbo Gan, Thomas Weimbs,
Sanford M Simon, Enrique
Rodriguez-Boulan (2003)
Three-dimensional analysis of
post-Golgi carrier exocytosis in
epithelial cells. Nature
Cell Biology. 5 :126-136.
Zahra Mamdouh, Xia Chen,
Lynda M. Pierini, Frederick R.
Maxfield, William A. Muller
(2003) Targeted recycling of
PECAM from endothelial
surface-connected compartments
during diapedesis. Nature.
421 :748-753.
J僡gen Wendland (2003)
Analysis of the landmark protein
Bud3 of Ashbya gossypii reveals
a novel role in septum
construction. EMBO
Reports. 4 :200-204.
David J. Milan, MD; Travis A.
Peterson, BS; Jeremy N. Ruskin,
MD; (2003) Drugs That Induce
Repolarization Abnormalities
Cause Bradycardia in Zebrafish. Circulation.
107 :1355-1358.
Xu C., Watras J., Loew L. M.
(2003) Kinetic analysis of
receptor-activated
phosphoinositide turnover. Journal
of Cell Biology. 161
:779-791.
Barkalow K. L., Italiano J.
E., Chou D. E., Matsuoka Y.,
Bennett V., Hartwig J. H. (2003)
{alpha}-Adducin dissociates from
F-actin and spectrin during
platelet activation. Journal
of Cell Biology. 161
:557-570.
Jacquet M., Renault G.,
Lallet S., De Mey J., Goldbeter
A. (2003) Oscillatory
nucleocytoplasmic shuttling of
the general stress response
transcriptional activators Msn2
and Msn4 in Saccharomyces
cerevisiae. Journal
of Cell Biology. 161
:497-505.
van Breugel M., Drechsel D.,
Hyman A. (2003) Stu2p, the
budding yeast member of the
conserved Dis1/XMAP215 family of
microtubule-associated proteins
is a plus end-binding
microtubule destabilizer. Journal
of Cell Biology. 161
:359-369.
Pidoux A. L., Richardson W.,
Allshire R. C. (2003) Sim4: a
novel fission yeast kinetochore
protein required for centromeric
silencing and chromosome
segregation. Journal
of Cell Biology. 161
:295-307.
Shirasu-Hiza M., Coughlin P.,
Mitchison T. (2003)
Identification of XMAP215 as a
microtubule-destabilizing factor
in Xenopus egg extract by
biochemical purification. Journal
of Cell Biology. 161
:349-358.
Garvalov B. K., Higgins T.
E., Sutherland J. D., Zettl M.,
Scaplehorn N., Kocher T.,
Piddini E., Griffiths G., Way M.
(2003) The conformational state
of Tes regulates its zyxin-dependent
recruitment to focal adhesions. Journal
of Cell Biology. 161 :33-39.
Engelholm L. H., List K.,
Netzel-Arnett S., Cukierman E.,
Mitola D. J., Aaronson H.,
Kjoller L., Larsen J. K., Yamada
K. M., Strickland D. K.,
Holmbeck K., Dano K., Birkedal-Hansen
H., Behrendt N., Bugge T. H.
(2003) uPARAP/Endo180 is
essential for cellular uptake of
collagen and promotes fibroblast
collagen adhesion. Journal
of Cell Biology. 160
:1009-1015.
Tsou M.-F. B., Ku W., Hayashi
A., Rose L. S. (2003)
PAR-dependent and
geometry-dependent mechanisms of
spindle positioning. Journal
of Cell Biology. 160
:845-855.
Vignjevic D., Yarar D., Welch
M. D., Peloquin J., Svitkina T.,
Borisy G. G. (2003) Formation of
filopodia-like bundles in vitro
from a dendritic network. Journal
of Cell Biology. 160
:951-962.
|
|
E. Casademunt,
T.R. Varney, J. Dolman, C.
Petty, D.D. Blumberg (2002) A
gene encoding a novel
anti-adhesive protein is
expressed in growing cells and
restricted to anterior-like
cells during development of
Dictyostelium. Differentiation.
70 :23-35.
T.R. Varney, E. Casademunt,
H. Ho, C. Petty, J. Dolman, D.D.
Blumberg (2002) A novel
Dictyostelium gene encoding
multiple repeats of adhesion
inhibitor-like domains has
effects on cell-cell and
cell-substratum adhesion. Developmental
Biology. 243 :226-248.
T.R Varney, H. Ho, C. Petty,
D.D. Blumberg (2002) A novel
disintegrin domain protein
affects early cell fate
specification and pattern
formation in Dictyostelium. Development.
129 :2381-2389.
Lance A. Davidson, Benjamin
G. Hoffstrom, Raymond Keller,
and Douglas W. DeSimone (2002)
Mesendoderm Extension and Mantle
Closure in Xenopus laevis
Gastrulation: Combined Roles for
Integrin aB, Fibronectin, and
Tissue Geometry Developmental
Biology. 242 :109-129.
Yvon A.-M. C., Walker J. W.,
Danowski B., Fagerstrom C.,
Khodjakov A., Wadsworth P.
(2002) Centrosome Reorientation
in Wound-Edge Cells Is Cell Type
Specific Molecular
Biology of the Cell. 13
:1871-1880.
Matuliene J., Kuriyama R.
(2002) Kinesin-like Protein CHO1
Is Required for the Formation of
Midbody Matrix and the
Completion of Cytokinesis in
Mammalian Cells Molecular
Biology of the Cell. 13
:1832-1845.
Wu X., Wang F., Rao K.,
Sellers J. R., Hammer J. A.
(2002) Rab27a Is an Essential
Component of Melanosome Receptor
for Myosin Va Molecular
Biology of the Cell. 13
:1735-1749.
Padilla P. A., Nystul T. G.,
Zager R. A., Johnson A. C.M.,
Roth M. B. (2002)
Dephosphorylation of Cell
Cycle-regulated Proteins
Correlates with Anoxia-induced
Suspended Animation in
Caenorhabditis elegans Molecular
Biology of the Cell. 13
:1473-1483.
Hoepfner D., Schaerer F.,
Brachat A., Wach A., Philippsen
P. (2002) Reorientation of
Mispositioned Spindles in Short
Astral Microtubule Mutant
spc72Delta Is Dependent on
Spindle Pole Body Outer Plaque
and Kar3 Motor Protein Molecular
Biology of the Cell. 13
:1366-1380.
Sawhney R. K., Howard J.
(2002) Slow local movements of
collagen fibers by fibroblasts
drive the rapid global
self-organization of collagen
gels Journal
of Cell Biology. 157
:1083-1092.
Zhao M., Jin T., McCaig C.
D., Forrester J. V., Devreotes
P. N. (2002) Genetic analysis of
the role of G protein-coupled
receptor signaling in
electrotaxis Journal
of Cell Biology. 157
:921-928.
Hannak E., Oegema K., Kirkham
M., Gonczy P., Habermann B.,
Hyman A. A. (2002) The
kinetically dominant assembly
pathway for centrosomal asters
in Caenorhabditis elegans is
{gamma}-tubulin dependent Journal
of Cell Biology. 157
:591-602.
O'Brien R., Xu D., Mi R.,
Tang X., Hopf C., Worley P.
(2002) Synaptically Targeted
Narp Plays an Essential Role in
the Aggregation of AMPA
Receptors at Excitatory Synapses
in Cultured Spinal Neurons Journal
of Neuroscience. 22
:4487-4498.
Connors N. C., Kofuji P.
(2002) Dystrophin Dp71 Is
Critical for the Clustered
Localization of Potassium
Channels in Retinal Glial Cells Journal
of Neuroscience. 22
:4321-4327.
David A. Zacharias, Jonathan
D. Violin, Alexandra C. Newton,
and Roger Y. Tsien (2002)
Partitioning of Lipid-Modified
Monomeric GFPs into Membrane
Microdomains of Live Cells Science.
296 :913-916.
Li J., Puceat M., Perez-Terzic
C., Mery A., Nakamura K.,
Michalak M., Krause K.-H.,
Jaconi M. E. (2002) Calreticulin
reveals a critical Ca2+
checkpoint in cardiac
myofibrillogenesis Journal
of Cell Biology. 158
:103-113.
Salmon W. C., Adams M. C.,
Waterman-Storer C. M. (2002)
Dual-wavelength fluorescent
speckle microscopy reveals
coupling of microtubule and
actin movements in migrating
cells Journal
of Cell Biology. 158 :31-37.
Deborah A. Hogen and Roberto
Kolter* (2002) Pseudomonas-
Candida Interactions: An
Ecological Role for Virulence
Factors Science.
296 :2229-2232.
C. Hudson, R. Oakley, R.
Cruickshank, S. Rhem, C. Loomis
(2002) Automation and validation
of the Transfluor(tm)
technology: a universal
screening assay for G
protein-coupled receptors
Biomedical Nanotechnology
Architectures and Applications.
4626 :548-555.
Funamoto S, Meili R, Lee S,
Parry L, Firtel RA (2002)
Spatial and temporal regulation
of 3-phosphoinositides by PI
3-kinase and PTEN mediates
chemotaxis. Cell.
109 :611-23.
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高階螢光離子流影像處理分析軟體,
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