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LEICA
CW 4000 Cytogenetics Workstation
在 Molecular
Cytogenetics 的技術與儀器,
我們專精於創新的染色體與細胞基因影像技術與影像系統儀器及軟體.
提供全方位的創新解決方法 (
Innovative Application Solution - Multi-Colour
Karyotyping 及 Spectral-Karyotyping).
在國外原廠的支援及國內醫學院的合作下,
成功的引進多套的染色體頻譜影像分析系統
, 架構單一系統供
SKY,
FISH, Multi-FISH, CGH, DAPI-Imaging, G-Banding 等比對分析工作.
美嘉儀器除了公司本身具有多位原廠訓練合格的工程師專員外,
另聘有專業的研究所的技術專員,
爲您解決所有的問題.
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Leica
CW 4000
Cytogenetics Workstation |
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Leica
Karyotyping |
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Leica
FISH |
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Leica
MFISH ( Multi-Color FISH ) |
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Leica
CGH |
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Leica
SatCap |
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Leica
CW 4000 Cytogenetics
Workstation |
| 應用模組包括
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 Karyotyping
( 染色體比對 ) |
| FISH
( Fluorescence In-Situ Hybridisation ) 螢光雜染技術 |
| CGH
( Application for Cancer & Pathology ) |
| MFISH
( Multi-Color Chromosome Karyotyping ) |
| SatCap
( 遠距網路架構 ) |
| 全自動
Leica DM
RXA 2 螢光顯微鏡及數位相機 |
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| Leica
CW 4000
特點 : |
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分析軟體模組化 (
可依用戶應用與經費作規劃選配 ). |
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應用軟體使用簡易, 先進技術,
功能完善, 軟硬體皆為 LEICA
公司整體開發設計與製造. |
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全自動螢光顯微鏡,
確保 Zero-Pixel-Shift.
備有不同解析的冷卻式
CCD 攝影機.
提供最高光學解析. |
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專業的教用與技術支援服務,
確保永續使用. |
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LEICA
CW4000 Application Modules ( 應用模組
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Leica
CW 4000 Karyotyping
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Leica
CW4000 karyotyping application provides a
breakthrough in cytogenetic image quality.
With up to 12 Mpixel image resolution, more
detail is evident than in comparable images
captured with standard video CCD technology.
Leica CW4000 Karyotyping offers:
Highest possible resolution images for
Karyotyping. Fast efficient, accurate
karyotyping enhanced by superior
segmentation tools, and neural network
classification techniques. This ensures
unrivalled accuracy, saving you time whilst
increasing throughput. No
requirement to delete background during
thresholding (detection of chromosome
boundaries). CW4000 handles images
intelligently – this means that there is
no risk of permanent deletion of telomeres
and satellites by "over thresholding",
and you gain total confidence in your
results. Human and non human karyotyping
included as standard – no need to buy an
extra module for Research projects.
Karyogram layouts are included for rat,
mouse, cattle, wheat, pig and human. New
layouts are simple to generate. The
ability to effortlessly karyotype FISH
images (either human or non human) using the
inverted counterstain image (requires CGH
option). Extereme Ratio Detection - allows
the operator to display only red/green
pixels from a fluorochrome above or below
certain intensity (ratio) levels. This can
be used in Cross Species painting
experiments to examine the image for areas
of homology between two different species.
Extensive karyotyping enhancement and
presentation tools, presented in a logical,
workflow approach. |
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Leica
CW4000 FISH ( Fluorescence In-situ
Hybridization )
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Fluorescence
image acquisition and advanced analysis
tools for cytogeneticists are provided by
the Leica CW4000 FISH application. Optional
high resolution imaging provides total
confidence in your results, whether for
standard FISH assays or the capture of
images for in-depth CGH or MFISH analysis.
Further flexibility is provided by Z-Stack
capture and processing, allowing the
accurate display of probe signals for tissue
and interphase samples. Leica CW4000 FISH
provides:
- Acquisition
facilities for up to 8 image planes,
allowing the capture of combinatorial
MFISH and CGH images.
- MFISH
metaphase analysis tools which are
adaptable to different combinatorial
labelling schemes.
- The
ability to import .tif images from any
original source for further analysis.
- Full
compatibility with karyotyping
applications to allow flexible
karyotyping of 2, 3 or multi-colour
images.
- Maximum
sensitivity and absolute registration
where required, in the production of
multi-probe fluorescent images.
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Leica
CW4000 CGH
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The
combination of accurate karyotyping with
advanced CGH analysis tools, provides the
most powerful CGH system commercially
available. Additionally, the incorporation
of digital camera technology delivers
unrivalled high resolution CGH analysis,
whilst the streamlined karyotyping tools
make the system suitable for research and
routine studies. Leica CW4000 CGH offers:
- Fast
and efficient comparisons of results
through simultaneous multiple displays.
- Accurate
classification adaptable to multiple
species including human, mouse and rat.
- An
interactive ratio normalisation
facility.
- An
optional ability to threshold a combined
inverted DAPI and reference image mask
ensuring complete inclusion of telomeres.
- A
ratio image viewing facility of
metaphase and karyogram.
- Quality
control measurements including,
coefficient of variation, dynamic range,
homogeneity and granularity.
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Leica
CW4000 MFISH ( Multi-Color FISH )
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The
Leica CW4000 MFISH application is a
versatile, leading edge analysis tool which
reflects the need for a flexible multi-colour
imaging system, as highlighted by recent
developments in MFISH technology.
The applications flexibility is shown in
it's proven ability to:
- Analyse
samples from combinatorial labelling
schemes using 5, 6 or 7 fluorochromes.
- Study
whole chromosomes, telomeres or specific
regions of chromosomes.
- Adapt
to the study of samples from any species
- An
image to be displayed as a metaphase,
karyogram, classification or a rendered
coloured image.
- Dynamic
separation of touching and overlapping
chromosomes.
- The
classification of each pixel according
to a combinatorial labelling scheme.
- Simultaneous
display of all fluorochrome components
from selected chromosomes.
- Probe
meter indication of relative
fluorochrome intensities and chromosome
classification at selected pixels.
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Leica
CW4000 SatCap ( 網路系統
)
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The
Leica CW4000 Satellite Capture Station
incorporates a computer workstation, monitor
and full image acquisition facilities for
brightfield applications, to allow
acquisition and subsequent metaphase
analysis to be performed. Captured images
are exported and archived across the network
using Cybase, the internal patient database,
to allow full accessibility and
interactivity with the images. Leica CW4000
SatCap gives you :
- An
economical network solution for
cytogenetics laboratories.
- A
dynamic solution that effectively
improves laboratory throughput.
- The
ability to archive images directly to
the Leica CW4000 database for retrieval
and review at a later date.
- The
option of employing two cameras per
workstation to further increase
productivity.
- An
economical alternative to traditional
photographic techniques
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