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Karyotyping
Software
High resolution megapixel digital CCD
camera, 1280 x 1024 spatial resolution, with
12-bit dynamic range (4096 gray scales)
Image Capture with automatic or
manual exposure and contrast controls.
Image Enhancement (Contrast,
Sharpening, Straightening, Rotation, etc.)
Automatic Separation of overlapping
Chromosomes
Automated Counting of Chromosomes
Ability to document XY coordinates
and slide label information within
Acquisition Mode without having to switch
back to Case Data Manager
Active, fulltime viewing of
chromosomes while being repositioned within
the karyotype table.
Chromosome Annotation Capabilities
including text and graphics, with reference
to ISCN Nomenclature of Ideograms
Annotation capabilities provided
within Microsoft Paint (included), or the
ability to link annotation to other programs
(i.e. Photoshop, Powerpoint, etc.) of the
user’s choice
Report Generation, with saving of
files as *.snp filetypes for shareability.
Image Database with automated
chromosome classifier G, R, Q, and DAPI
Banding Patterns
Network Functionality with autonomous
capability
Interface to Shire Genetics Software
System: Dual direction
Compatibility to Safely Transfer Case
Images between offsite computer stations
with similar capability
Ability to clean and re-initialize
terminals independently without powering
down the network
Network capability of 25+ stations
Ability to create and print graphical
statistics for department administration,
including workflow, sample distribution,
case distribution per technician, etc.
Description of activity history log
capabilities of software:
o
Case
Data Manager database maintains
identification of technician or
cytogeneticist working on case.
o
Karyotype
results, as well as counting results, are
updated automatically in the database. Any
change of the karyotyping results will open
a new line entry in the results fields and
documented automatically. Hence, histories
of previous analysis are kept.
o
Operations
done in the metaphase and karyotype are
saved in the *.bnd file. Original data is
always maintained! When a previous
analyzed cell is loaded, previous user
operations are done automatically on the
original data to bring it back to its latest
status.
o
History
log is under consideration for development,
and will be implemented if required by NYGH.
BandView
Features
High
resolution images with 12-bit digital CCD-camera
(1280 x 1024 pixels)
Wide
field-of-view (2/3”) for capturing widely
spread metaphases in one image acquisition
Ability
to join numerous frames, connecting even
very sparse metaphases, including gallery of
the individual frame to validate full
coverage
Extremely
low dark noise allowing for long exposure
times
Automatically
adapted to both brightfield, phase contrast
and epi-fluorescence — no need to adjust
the microscope illumination during the image
acquisition (1 mSec to 10 Sec)
Automatically
adapted to any objective magnification
Live
view of image with optimal contrast is
displayed throughout image acquisition
Powerful
user-interface for quick, simple image
acquisition
Background
displayed as either white or gray values,
allowing the ability to validate that no
part of the image, such as
faint telomeric regions, has been
missed
Inclusion
of chromosome parts, such as markers, at any
point in the analysis process
Availability
of all tools, such as shape editing,
contrast and sharpness changes, at any stage
of the analysis process
Karyotyping
at any stage in the analysis process, even
before segmentation has been finalized
Automatic
background correction, which accurately
resolves highly non-uniform microscope
illumination to allow for optimized
segmentation
Analysis
with all objective magnifications, without
the need to change the C-mount or
recalibrate the system parameters when the
objective is changed
Superb
automatic contrast to minimize effect of
small debris in the metaphase
Customized
settings, such as the Band Enhancement
level, can be saved and applied
automatically on each new image
Automatic
separation of touching
Highly
robust and efficient tools to correct
chromosome contours and to resolve highly
complex chromosome spreads
Definable
“Undo” for removal of up to 10 steps in
the analysis process.
10-level
enhancement of fine band detail in
brightfield and fluorescence
Enhance
individual chromosomes, including linear and
non-linear brightness and contrast controls
Restore
original contrast and brightness in one
click
Advanced
color control for precise brightness and
contrast adjustments
All
original image data always maintained
Easy
separation of touching and overlapping
chromosomes
Automated
classification of brightfield or
fluorescently-labeled metaphases
Proprietary
background subtraction enables automatic
chromosome segmentation on sub‑optimal
metaphases
Chromosome
classifier libraries to improve original
chromosome placement
400-,
550-, 850- band level ideograms based on
ISCN‑1995 nomenclature
Robust
comparison tool to simultaneously compare
multiple chromosome classes
Dynamic
karyotype table to fit any number of
chromosomes
Multiple
drag and drop for transferring and replacing
chromosomes
Intuitive
user interface, such as seeing the
chromosomes as they are dragged in the
karyotype table.
Generation
of Reports
Flexible
report generation to include any combination
of data, including metaphase, karyotype and
case data information, physician reports and
analyzed cells report
Customizable
design of Report Templates to accommodate
user’s requirements
Graphical
Reports of Statistics: distribution of cases
analyzed over time, per Technician,
Physician, Specimen Type, etc.
Comparison
reports of multiple cells from the same or
different cases, optionally combining
results of G-Band, FISH and SKY in the same
report.
Flexible
page layout
Easy-to-use
annotation tools
Compatibility
with any printer with a Windows XP driver
Customizable
workspace
Flexible
use with any computer monitor —including
laptops— at any screen resolution
Easy
arrangement of screen windows to fit your
personal work style
Practically
unlimited zoom levels for any screen window
Flexible
karyotype table stretches automatically to
fit any arrangement, including unlimited
number of chromosomes in a class
Customized
karyotype view with the ability to show any
or all of the following side-by-side in the
karyotype: original chromosome, straightened
chromosome, ideogram, banding profile, and
breakpoint locations
Management
of image
data
Robust
image database for all ASI applications
allowing viewing of all analyses of a
particular case, including SKY™ and
FISH.
Powerful
search utility that can filter by any field,
including text strings
Convenient
image gallery to spot cases by metaphase or
karyotype
Immediate
access to all patient data in one mouse
click
Direct
archiving to any storage media
Extensive
network capabilities for multiple systems
and workstations
Upgrade
to SKY™ and FISH
Seamless
upgrade to SKY™ with the simple
addition of an optical head — no need to
purchase an additional camera
Software
upgrade to FISHView™, ASI’s FISH
analysis system
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